NURS 6630 week 10 Assignment 2: SPECIAL CONSIDERATIONS FOR PATIENT POPULATIONS PAPER

Solution:

Special Considerations for Patient Populations

The use of medications in lactating mothers diagnosed with major depressive disorder (MDD) with postpartum/ post-partum depression (PDD) must be informed by a cautious evaluation of potential benefits and risks based on current research, clinical expertise, and patient values and preferences (Kaufman et al., 2022). Without appropriate treatment, PPD can result in adverse complications in the mother’s and child’s cognitive, physical, emotional, and behavioral health (Simas et al., 2022). This paper focuses on the case of a woman diagnosed with MDD with postpartum depression. It includes a discussion of the most appropriate treatment of choice among lithium, sertraline, and paroxetine, with rationale, dosing schedules, necessary patient education, necessary labs/ diagnostics, monitoring efficacy and side effects, additional collaboration, and treatment (alternative plan) for patients who are non-adherent to treatment.

Selected Treatment with Rationale, Why Other Drugs are Not Appropriate

The selected treatment for the breastfeeding mother experiencing PPD is sertraline. Sertraline is a selective serotonin reuptake inhibitor (SSRI) used as a first-line treatment for PPD due to its proven efficacy and safety profile for lactating women (Kaufman et al., 2022; Stika et al., 2022). It has the lowest transfer to breast milk and with minimal adverse effects on the infants, making it the most preferred treatment of choice in lactating women (Ushkalova & Ushkalova, 2023). Lithium is not typically recommended during pregnancy due to its accumulation in infants (potential for lithium toxicity) and side effects of lethargy, thyroid dysfunction, and poor feeding (Chokhawala et al., 2024). Moreover, the patient does not present psychosis symptoms, ruling out the need for a mood stabilizer. Paroxetine is also an SSRI with proven efficacy and safety in the treatment of PPD (Kaufman et al., 2022). However, compared to sertraline, it has higher concentrations in breast milk and thus, higher adverse effects of sedation and poor weight gain in breast infants (Ushkalova & Ushkalova, 2023).

Dosing Considerations

The typical starting Sertraline dosage for PPD is 50 mg once a day